Core Readings

Core readings for this program come from Designing Clinical Research, 3rd Edition by Stephen B. Hulley and co-authors. 

This indispensable text belongs in every scholar’s library.

Supplemental Readings

1. Introduction

Luke R. Online interprofessional health sciences education: from theory to practice. J Cont Health Educ Prof 2009.

Silver I. Faculty development for continuing interprofessional education and collaborative practice. J Cont Health Educ Prof 2009.

McKinney D. iTunes university and the classroom: can podcasts replace professors? Computers Educ 2009. 

2. Why Do Research?

Woods D. Can students and practicing doctors do medical research and should they? CMAJ 1979.

Dransfield B. Why does medical research sometimes get it so wrong? SACEMA 2011.

Summers RL. Assessment of the “scholarly project” requirement for emergency medicine residents: report of the SAEM Research Directors’ Workshop. Acad Emerg Med 1999.

3. Scholarship Defined

Boyer EL. Clinical practice as scholarship. Holist Nurs Pract 1996.

Lewis R. Educational research: time to reach the bar, not lower it. Acad Emerg Med 2005.

Lowenstein S. Tuesdays to write...a guide to time management in academic emergency medicine. Acad Emerg Med 2008.

4. Developing The Question

Boyer E. Conducting drug abuse investigations in natural environments: potential directions for medical toxicology research. J Med Toxicol 2010.

5. In Defense of Case Reports

Hill AB. The environment and disease: association or causation? Proc Royal Soc Med 1965.

Vandenbroucke JP. In defense of case reports and case series. Ann Intern Med 2001.

Albrecht J. Case reports and case series from Lancet had significant impact on medical literature.  J Clin Epidem 2005.

Hoffman RS. What to do with case reports? Is folly that succeeds folly nonetheless? Clin Tox 2003.

Ruha A-M. The case report: a tool for the toxicologist. J Med Toxicol 2009.

Erickson TB. Acute renal toxicity after ingestion of lava light liquid. Ann Emerg Med 1996.

Mortelmans LJM. Seizures and hyponatremia after excessive intake of diet coke. Euro J Emerg Med 2008.

6. Study Design Basics

Hartman JM. Tutorials in clinical research: recognizing and controlling bias. Laryngoscope 2002.

Benson K. A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000.

Wakefield AJ. Illeal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998

7. Navigating The IRB

Weinberg JM. Good study design and analysis plans as features of ethical research with humans. Ethics Hum Research 2003.

McRae A. US federal regulations for emergency research: a practical guide and commentary. Acad Emerg Med 2008.

Roberts J. An author’s guide to publication ethics: a review of emerging standards in biomedical journals. Headache 2009.

8. Case-Control Studies

O’Brien K. Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. JAMA 1998.

Manini AF. Utility of serum lactate to predict drug-overdose fatality. Clin Tox 2010.

Gomes T. Opioid dose and drug-related mortality in patients with nonmalignant pain. Arch Intern Med 2011.

9. Retrospective Strength

Gilbert EH. Chart reviews in emergency medicine: where are the methods? Ann Emerg Med 2000.

Lung DL. Hypoglycemia in pediatric sulfonylurea poisoning: an 8-year poison center retrospective study. Pediatrics 2011.

Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Tox 2007.

Worster A. Understanding medical record review (MRR) studies. Acad Emerg Med 2004

10. Cohort Studies

Woods SW. Incidence of tardive dyskinesia awith atypical and conventional antipsychotic medications: prospective cohort study. J Clin Psych 2010.

Larsson SC. Coffee consumption and risk of stroke in women. Stroke 2011.

11. Cross-Sectional Studies

Bjornaas MA. Suicidal intention, psychosocial factors and referal to further treatment: a one-year cross-sectional study of self-poisoning. BMC Psychiatry 2010.

Schober SE. Blood mercury levels in US children and women of childbearing age, 1999-2000. JAMA 2003.

12. Randomized Clinical Trial

Marshall G. Streptomycin treatment of pulmonary tuberculosis. BMJ 1948.    **The very 1st published RCT**

Fasano CJ. Comparison of octreotide and standard therapy versus standard therapy alone for the treatment of sulfonylurea-induced hypoglycemia. Ann Emerg Med 2008.

Bryant SM. Pretreating rats with parenteral ophthalmic antimuscarinic agents decreases mortality from lethal organophosphate poisoning. Acad Emerg Med 2007.

Smith C. Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of controlled trials. BMJ 2003.

Clinical trial registration: a statement from the international committee of medical journal editors. N Engl J Med 2004.

CONSORT 2010 checklist

CONSORT 2010 flow diagram

13. Survey Studies

Levav J. When questions change behavior: the role of ease of representation. Psychol Science 2006.

Zwane AP. Being surveyed can change later behavior and related parameter estimates. PNAS 2011.

O’Brien MC. Caffeinated cocktails: energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Acad Emerg Med 2008.

Beauchamp G. Making surveys count. J Med Toxicol 2016

14. Scholarship of Teaching

Lewis R. Educational research: time to reach the bar, not lower it. Acad Emerg Med 2005.

Ende J. Feedback in clinical medical education. JAMA 1983.

Fincher R. Perspectives on the scholarship of teaching. Med Educ 2006.

Yarris L. Education research: a primer for educators in emergency medicine. Acad Emerg Med 2011.

Kessler C. Moving beyond confidence and competence: educational outcomes research in emergency medicine. Acad Emerg Med 2011.

15. Data Management

Theodore BR. Management and interpretation of data obtained from clinical trials in pain management. World Instit Pain 2008.

16. & 17. Statistical Nuts and Bolts I & II

Jones J. Research fundamentals: statistical considerations in research design: a simple person’s approach. Acad Emerg Med 2000.

Kusuoka H. Advice on statistical analysis for Circulation Research. Circ Res 2002.

Lewis RJ. Introduction to statistics. SAEM Conference 2006.

Altman DG. Absence of evidence is not evidence of absence. BMJ 1995.

Katz M. Multivariable analysis: a primer for readers of medical research. Ann Emerg Med 2003.

Gallagher J. P<0.05: Threshold for decerebrate genulflection. Acad Emerg Med 1999.

Molina DK. Fatal cocaine interactions. A review of cocaine-related deaths in Bexar County, Texas. Am J Forens Med Path 2011.

18. Anatomy of an Abstract

Winsett RP. How to prepare an abstract. NATCO 2008.

Taboulet P. Advice on writing an abstract for a scientific meeting and on the evaluation of abstracts by selection committees. Euro J Emerg Med 2000.

SAEM Abstract Scoring 2014

19. Developing a Manuscript

Docherty M. The case for structuring the discussion of scientific papers. BMJ 1999.

Paton A. How I write a paper. BMJ 1976.

Singer AJ. How to write a manuscript. J Emerg Med 2009.

Peregrin T. How to cope with rejection. J Amer Diet Assoc 2007.

Lilleyman JS. How to write a scientific paper - a rough guide to getting published. Arch Dis Childhood 1995.

Podolsky SH. The evolving roles of the medical journal. N Engl J Med 2012.

20. Scholarship Assessed

Glassick CE. Boyer’s expanded definitions of scholarship, the standards of assessing scholarship, and the elusiveness of the scholarship of teaching. Acad Med 2000.